Pancreatic stone protein levels accurately predict severity in sepsis of various causes earlier than other biomarkers. Author: Kouroupis
Abstract
This study evaluates the prognostic value of Pancreatic Stone Protein (PSP) in sepsis compared to conventional biomarkers (WBC, CRP, PCT). Conducted in an emergency department setting, the study included 28 patients with sepsis of diverse origins (respiratory, urinary, bloodstream infections, etc.). PSP levels were measured using the abioSCOPE® with an IVD CAPSULE PSP, leveraging nanofluidic technology to deliver results in 5 minutes. PSP levels were significantly higher in Gram-negative sepsis and bacteremia, correlating with worse outcomes (*p* = 0.006). Unlike WBC, CRP, and PCT, PSP predicted severity and mortality earlier, upon admission, while other biomarkers only showed prognostic significance 48 hours later. PSP also associated with acute kidney injury (*p* = 0.027) and was elevated in bloodstream infections (mean 378 ng/ml).
The findings suggest PSP’s superior early risk-stratification potential for sepsis, advocating its clinical utility in emergency settings.